Wellbutrin XL is one of the only anti-depressants that begins to work fairly quickly in most people. Remember that drugs affect people differently. I LOVE Wellbutrin XL, but can't take more than 150mg without debilitating headaches. I have taken both the generic and brand and have not noticed any difference.

I would check with your prescribing doctor and pharmacist to make sure you are not having an interaction with another drug.

This is now day 5 on wellbutrin XL and I am feeling more awake. In fact I stayed up pretty late last night without being tired and had somewhat of a hard time getting to sleep. I have been waking up earlier than usual also. I have not had the foggy mind/blurred vision for the last few days. My mind is clearer. I still feel no effect on my appetite. No weight loss yet. I was so worried that I would have the nasty side effects everyone is talking about (it may still happen, I know). I don't feel more anxiety at all, in fact I feel a little more laid back and rational (I am taking it for social anxiety and mild underlying depression). I had a slight headache on/off the first day, but I was also coming off lexapro 10mg. I do notice that my resting heart rate is a little higher (normally in the 50's-60's and now in the mid-upper 70's). I was worried that my BP would be through the roof, as it has run high in the past, but I've checked it the last couple nights (I'm a nurse) at it was surprisingly low for me (117/78). I think the insomnia thing may be an issue soon, since I am rarely feeling tired now. I usually take melatonin, but I'm not sure if that will work now. My doc only gave me 10 ambiens a month ago (I always seem to find the docs that are very reluctant to give out any such meds- I really don't think I come off as a drug seeker- I'm a shy RN). Ambien works very well for me. Anyone know of a good psychiatrist in the Chicago area? I'm not sure if I like mine- I've only seen him twice so far...