I am taking metoprolol, vasotec, and xanax for high BP and anxiety. My doc doubled my dosage of metoprolol about a year ago because of heart palpitations. Lately I am feeling lousy and I am almost positive it's the metoprolol. Numbness in hands, lightheadedness, cold all over, constant fatigue, generally crummy. I am going to call my doc about this tomorrow. I have already cut my dosage in half because I can't take this.