1st November 2004
Quote from zip2play:Myopathy hurts (it means muscle pain), and those people who get it bad from statins would probably discontinue them.
Myopathy is more than just "muscle pain". Myopathy can range from a cramp to Rhabdomyolysis [Rhabdomyolysis is the breakdown of muscle fibers resulting in the release of muscle fiber contents into the circulation. Some of these are toxic to the kidney and frequenty result in kidney damage.]
Definition from the National Institute of Neurological Disorders and Stroke:
What is Myopathy?
The myopathies are neuromuscular disorders in which the primary symptom is muscle weakness due to dysfunction of muscle fiber. Other symptoms of myopathy can include muscle cramps, stiffness, and spasm. Myopathies can be inherited (such as the muscular dystrophies) or acquired (such as common muscle cramps).
Myopathies are grouped as follows:
- a simple classification of myopathy:-
Hereditary
muscular dystrophies
congenital myopathies
myotonias
channelopathies (periodic paralysis syndromes)
metabolic myopathies
mitochondrial myopathies
Acquired
inflammatory myopathy
endocrine myopathies
drug-induced/toxic myopathies
myopathy associated with systemic illness
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Drug-induced myopathy
lipid-lowering agents (statins, clofibrate and gemfibrizol)
agents that cause hypokalemia (diuretics, theophylline, amphotericin B)
lithium
succinylcholine
antibiotics (trimethoprim, isoniazid)
anticonvulsants (valproic acid, lamotrigine, prolonged propofol infusion)
vasopressin
colchicine, episilon aminocaproic acid, high dose alfa-interferon
illicit drugs (cocaine, heroin, phencyclidine, amphetamines)
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My point was that statins deplete the body of CoQ10. Low levels of CoQ10
can cause myopathy. Myopathy can make it difficult or impossible to
exercise. A rather vicious circle.
