First of all, ptu has more side effects than tapazole but is safe during pregnancy. I think at least you should try 2 or 3 times a day instead of just once. Doctors think we won't comply if we have to take it 2 or 3 times a day, that's why they say that. I myself take 5 mgs of Methimazole once a day, 5 times a week, it seems to be okay for now. It probably will be lowered in a couple of months. I don't have hyper symptoms, even on the days I don't take it. I agree with you, RAI is really out of the question, nuke your thyroid? If you have subclinical, that's just crazy! I have always had a mild case, and my doc has had me on the MMI for a year and a half. Of course he brought up the RAI at the last visit(and he was being so good too!:confused:) Anyway, if you really can't tolerate the PTU, what about cutting the pill in half and try that instead, if he said you could actually go off it....50 ptu is equal to 5 methimazole, I think, so you are on more, but I've heard it is weaker. How were your levels when you were pregnant? Did you feel hyper then? I take it you weren't on meds when pregnant.