I am on Ortho Tricyclen lo and will soon be switching to the generic Ortho Tricyclen (Tri Sprintec) - due to insurance. The Ortho Tricyclen Lo helped with my breakouts, and it contained lower amounts of androgen binding hormones (the hormones that makes females break out) than the regular Ortho Tricyclen. My guess is that if the "Lo" version was effective, the regular Ortho Tricyclen will be just as effective, if not perhaps more. However, everyone's body will react differently to these new hormones. My doctor says to give a new pill 2-3 cycles. My guess is that it would be worth your time to give it a try. Good luck!