Hi all - I took frutels for 4 months or so, and did some research on how they work for acne. It's the B-5 or pantothenic acid. The frutels are expensive. GNC sells a bottle of pantothenic acid 500 for $11. One capsule has 5000% daily value. You can't o.d. on B vitamins because your body just eliminates the excess (you pee it out). Research suggests for severe acne you need a lot, some people report taking 20 a day!! I have been taking 4 to 6 a day. Also for women, try flax seed oil which has all three omega 3, 6, & 9 fatty acids which help to regulate hormones. Spearmint tea cuts oil down, green tea detoxifies - kroger sells a great green tea w/spearmint. Juliet's 3 step skin care system is great for healing/prevention. Or if you want to completely eliminate hormonal acne in women, ask your dr. for 100mg of spironolactone - look it up, it's not harmful to take. Not all dr.'s will prescribe it, find one that will. My acne is almost gone, and I won't have to take all this stuff anymore :) good luck all -