well I have tried erythromycin, tetracycline, minocycline, birth control pills, retin a, metrogel, clindagel, duac, not too mention all the over the counter meds....benzoyl peroxide, sulphur, etc...well I have been on spironolactone for 1 year now and my skin is nearly perfect. I do have spots from scarring, but nothing big. I am a 32 year old female, acne got worse with each pregnancy, so I think my acne was mostly hormonal maybe. But anyway I am on 100 mg a day, and it's not too expensive at all...$15 co-pay for me!