Okay...

My teacher she took Zoloft for 10 years now, and Zoloft stopped working for her. She become depressed, and she tried this drugs:

Paxil
Celexa
Effexor XR
Prozac

None of them helped, seemed like her brain totally made a tolerance againts SSRI's... So she was give Wellbutrin SR, and she is doing great she says... Her depression has improved!!!

Try to talk to your doctor about Wellbutrin SR its an
Norepenphrine/Dopamine Re-Uptake Inhibitor. I dont know if you tried it or not.

But your case sounds like you have developed tolerance to SSRI's...

I read some where, that if you have very horrible anxiety disorder, and panic disorder dont try wellbutrin SR... but ya could always give a try.

Also... Serzone could help too, its different than Effexor XR.

Effexor XR I believe it raises Serotonin/Norepenphrine...

And Serzone does the same, but its kinda different.

I found information how Serzone is different:

Antagonists (catchers glove cloggers)
There is another class of drug called an Antagonists. These make it harder for the catcher to catch the ball by clogging it up a little. Subsequently, the ball bounces into the space between the pitcher and catcher and then bounces around a bit. Examples of drugs that do this with serotonin are called Serzone and Desyrel.

[This message has been edited by Just-A-Boy (edited 03-21-2003).]

I HAVE PANIC DISORDER. I HAVE SENSITIVITY TO ALL MEDS AND IT IS DIFFICULT TO FIND THE RIGHT DOSES. I ALSO HAVE TROUBLE TRUSTING DR.S AND MEDICATIONS. IT COULD BE MY DISORDER AND THE FACT THAT I HAVE BEEN DOWN SOME DIFFICULT ROADS AT BEST WITH EITHER.I AM CURRENTLY TAKING PAXIL CR 12.5 MG DAILY. THIS IS MY 3RD DAY. I AM EXPERIENCING PROBLEMS SLEEPING AND TAKE THE PAXIL IN THE MORNING. I DON'T REALLY SEEM TO NOTICE ANY OTHER CHANGES. TONITE I HAVE HAD FEELINGS OF ANXIETY AND PANIC. I WAS ABLE TO WORK THROUGH THIS AND I CAN USUALLY WALK MYSELF THROUGH THESE EPISODES. IT IS DIFFICULT TO KNOW IF THIS WAS MY PANIC BROUGHT ON BY STRESS AS TODAY WAS DIIFICULT, OR THE MEDS? I SEEM TO BE DEVELOPING A SLIGHT RASH ON THE BASE OF MY NECK. LAST YEAR I HAD DIFICULTIES CONTROLLING THE PANIC AS MANY STRESSORS THAT WERE BEYOND MY CONTROL AND JUST HAD TO WAIT THEM OUT. THE DR. PRESCRIBED PAXIL AND THE NEXT DAY I JUST SLEPT ALL DAY NOT CONDUCIVE WITH SMALL CHILDREN RUNNING WILD. HE THEN SWITCHED ME TO WELLBUTRIN AT VERY SMAll DOSES, I THEN WENT INTO NON-STOP PANIC ATTACKS ACCOMPPANIED BY ACUTE ANXIETY FOR ONE AND A HALF WEEKS.THIS WAS INCREDIBLY UNBEARABLE FOR ME AND THE FAMILY. THE DR.BELEIVED THAT IT MAY BE A MANIC EPISODE ALTHOUGH I HAD NEVER HAD THIS BEFORE OR ANY DIAGNOSES OF THIS, REFERRED OUT TO PSYCH. NURSE TREATED FOR PANIC DISORDER AND GIVEN SERZONE HAD VISION AND MENTAL DISTURBANCE ON LOW DOSE. IT IS VERY DIFFICULT TO STAY ON THE MEDS AS MY ANXIETY USUALLY WORKS AGAINST THIS AND I HAVE CONTINUALLY HAVE TO EVALUATE THE WHETHER THIS ANXIETY OR REALITY AND I HAVE BEEN DOING FAIRLY WELL. I HAVE AGREED TO GIVE THIS MED 6 WEEKS AND WE WILL MEET IN 4 TO TAKE STOCK. I AM JUST NOT SURE THAT I CAN CONTINUE TO HAVE BROKEN RESTLESS SLEEP AS I HAVE YOUNG CHILDREN THAT ARE NEVER TIRED AND LIMITED RESOURCES. ON THE SAME TOKEN NEED TO SLEEP. I THINK THAT IF I STILL HAVE DIIFCULTY SLEEPING AFTER A FEW MORE DAYS I WILL CALL DR. I HAVE OTHER HEALTH CONCERNS AND TAKE PREVACID,ZANTAC And SEVERAL OVER THE COUNTER MEDS. I AM TRYING TO STABILZE MY STRESS LEVELS AND REGULATE HOW MY BODY RESPONDS TO THIS TO AVOID SURGERY. I AM JUST NOT SURE AS TO WHAT COURSE TO TAKE WITH MEDS, THE SIDE EFFECTS AND DR.S I HAVE ENCOUNTERED HAVE DEFINITLY MADE THIS WORSE AT TIMES. MY DOC NOW SEEMS TO BE ON THE BALL BUT IS JUST AN MD. I HAVE BEEN IN THERAPY YEARS BEFORE AND DO NOT HAVE COVERAGE FOR THIS NOW. I DO NOT FEEL THAT I HAVE ISSUES TO RESOLVE TO LESSEN THE ANXIETY, JUST WOULD LIKE TO ENJOY MY LIFE WITHOUT HAVING TO WORK THROUGH THESE EPISODES IT CAN BE VERY DIFFICULT AND TIRING AND WOULD JUST LIKE TO ENJOY MORE TIME LIVING.SIMPLESIMON

I hate to start being critical but when people start suggesting drugs that they are not fimiliar with by having been on them for years then this could get dangerous. I am all for as many of you as posssible to become drug free but lets face it, most of the posts show a lot more condition and fear then drug interactions. If you want to damage yourself permenately then keep quiting drugs cold turkey on your own by listening to others instead of doing it with professional help and learning about the halflifes, etc. of your drugs themselves. Take 10 times the the longest time, be it your Doctors or your opinion. You have to be able to tell if it is condition or withdrawal. Most of you from your posts have condition and justifiable fears because it is something that is not going to go away but it can be made better and very manageable. Questioning your Doctor or drug is one thing but continuously questing condition will never give you peace. Serzone is nothing like paxil or prozac, etc. It does work for anxiety and depression but interacts with drugs like xanax. It increases the intensity of these type of drugs, so if you go off of it to fast, you can be putting yourself at a high risk of injury. As far as seritonin it controls the animal in us all. For some an increase is definately needed. The military did a test during the Nam War where they tested the seritonin levels of 100 soldiers that enjoyed killing and 100 soldiers that did their duty but did not. They then tested 100 killers in prison and 100 inmates that did crimes that were not violent. All of the natural born killers of both tests had lower seritonin levels. Raising this level works to calm a person and their anxieties but also must be controled to the right level because to much seritonin will cause problems also. I believe most of the time people end up on to high a dose because instead of excepting their condition and trying to deal with eliminating the fear, they keep going back to the doctor freaking out and eventually get their dose upped which causes more panic because they never give their body time to adjust to any one dose. As far as the Europeans and Canadians writtings, gererally they are the ones that have tested the drugs and administered them for the longest time before we get the use of them. The problems is the interactions and side effects don't seem to get into Our Doctors hands fast enough. No Doctor has the time to be an expert on every drug. It is up to you to become the expert on the one or ones that you take. Don't fear learning about your drugs or condition, it is important that you know side effects from condition. Don't believe anyone book written by one Doctor or a Foundation for that matter unless it is backed by several other writtings and hopefullly someone with the condition itself. Everyone is different and you deserve to be diagnosised as such. Only you can control this by learning all you can. No depression, anxiety or panic attack symptoms have ever killed anyone but if you want to become disabled go off a drug to fast like I did a couple of years ago because I failed to learn about the drugs I was on. Not trying to scare anyone, I just would not worry myself with brain cells instead of getting a handle on your condition. You have enough to deal with just doing that. Lose the Fear and you will find the answer. I have symptoms all day and night. I deal with it and not by adding or upping my drugs. I have found Therapy (talking) to be more powerful then any drug. Not trying to offend anyone but I don't want anyone to get hurt by making hasty decisions. We are all ill and can probably never be the same person we were but I don't see why we can't strive to be a better one. Peace to you all.