I use oral syringes and squirt it into the pouch of ds's cheek. Or I've used a little bit of juice and put it into a nipple from a baby bottle and let him suck it down. There are a couple of drugs I've shot in that have come out -- septra and plain milk of magnesia. There are also pacifier medicine droppers -- put the medication in the pacifier and have the child suck on that.

Holding the nose shut or holding them down isn't a good idea. Don't want your child choking/aspirating on the medication. Plus it gets them really really mad and the next time you walk toward your child with an oral syringe or spoonful of medicine -- he'll fight and struggle all the way.