I took Remeron for about 8 months about a year ago. I had acne before I started taking it, and I still have acne now that I've stopped taking it. I don't think the Remeron had too much of an effect on my skin. If anything, the anti-anxiety effects of the drug reduced my stress level which may have made my skin better. HOWEVER, Remeron seemed to reduce the functioning of my thyroid gland, which can make acne worse, so maybe that is something to look into?