I take Nexium 40mg 2x/day and often suffer from nighttime reflux which interferes with sleep. I was taking Gaviscon which would be helpful for 2-4 hours but then I'd wake up with the same problem. My doctor prescribed Ranitidine so I take that before I go to bed and it is helpful though not perfect. Sorry, I don't know of a natural remedy to take while on PPIs, just regular medicine. Maybe someone else will know.