Not knowing what forum to look this under, I'll try this. Here is my question: Is it possible for Hormone Replacement Therapy to cause Cushing's Syndrome? I have been on HRT for about 7 years now (I am 47). First taking Premarin and now on Vivelle *** patch. In these last few years I have developed a hump on the back of my neck and a pot belly. Having acne, some facial hair, very tired just after climbing a few stairs and your regular moodiness. Up to now I have just ignored most of these signs but am becoming concerned with the hump and pot belly. I looked up signs leading to these and they all come back as Cushing's Syndrome. But most sites suggest this is caused by overuse of certain steriods. I am not on or have been on any other medications other than my HRT. Could my HRT be causing these sypmtoms? Should I discontinue my HRT and see if they go away? Or should I get tested for Cushing's Syndrome? Have any other females on HRT had any of these problems?? Any info I welcome. Thanks....Kim