Not in the past two years. My hubby and I were just discussing the fact that I am on premarin and that I maybe should up my dose. I had a total hysterectomy in Nov. 2002 and have been on it since. I am going to do some research on it right now. Thank you for helping me.

As of right now, my guess is that its gotta be something that you recently or has been recently changed in your life, that cirgerette like smell might be a pretty good lead. youd be surprised at what some of the chemicals there are these days in house hold products that can have a major effect on people, like brominated flame retardants, I wont get in to it cause itll probably just sound like im trying to use scare tactics or something like that lol. But anyways, any other thing that I could think of is that maybe your thyroid has started to go out, or maybe hypoglycemia, but the no weight gain usually rules those out so I wouldnt be to sure, youd have to run tests on those. The last thing that I can think of is a chemical imbalance(mineral/vitamin most likely). It starts to get more complicated in that area though, the edema, or swelling of the feet would be a good lead.

Just got your post while I was typing this, yah thats a pretty good idea, having low estrogen levels , which I think is what premarin would be for could be causing your symptoms, just make sure to run on a test on your estrogen levels etc... im sure you know what to do. Keep me updated on what happens if you will. Anyways no prob for the help, hope everything goes well.

Qaiphyx