23rd November 2003
Quote from pcovers:I have posted this is a couple of other threads, but I wanted to start a thread under the name policosanol so that others might see it. I'd be interested to hear if others have had the same positive benefits as I have.
I take 20MG/day. Raised my HDL from a very low 31 to a still low but much better 41. Over the last 8 years, which included at least 16 lipid profiles, my HDL never went above 31. After 8 weeks of taking 20MG/day of policosanol the two most recent lipid profiles both indicated 41. Also lowered my LDL by 25%.
Very safe. Many, many clicial trials. No known side effects. Made from Sugar cane. Nothing works for everyone, but it is worth serious cosnideration for anyone looking to lower cholesterol without using statins or other prescription drugs.
Policosanol is a mixture of fatty alcohols derived from the wax of sugar cane. These active substances work to lower cholesterol levels by several mechanisms. It inhibits cholesterol manufacturer but does so prior to HMG-CoA reductase. In addition policosanol also exerts exceptional effects on LDL-cholesterol metabolism. Specifically, policosanol increases LDL receptor processing. It exerts this effect by increasing the binding of LDL to its receptor, improving the transport of LDL into the liver cell, and significantly enhancing the breakdown of LDL cholesterol. In addition to lowering LDL, policosanol has also been shown to increase HDL, protect against free radical damage to LDL-cholesterol, and inhibit excessive platelet aggregation.
The clinical studies have included short and long-term, randomized, placebo-controlled and comparative studies versus statins (lovastatin, pravastatin and simvastatin), fibrates (bezafibrate and gemfibrozil), acipimox, and probucol involving nearly 3,000 subjects. In these studies, policosanol in dosages ranging from 5 to 20 mg/day, has demonstrated significant improvements in LDL-C, total cholesterol, HDL-C, and the ratios of total cholesterol to HDL-C and LDL-C to HDL-C. Policosanol produces cholesterol-lowering effects within the first 6-8 weeks of use. At a daily dosage of 10 mg of policosanol at night, LDL cholesterol levels typically drop by 20 to 25% within the first six months of therapy. At a dosage of 20 mg, LDL levels typically drop by 25-30%. HDL cholesterol levels typically increase by 15 to 25% after only two months of use. The combined LDL reduction and HDL increase can produce dramatic improvements in the LDL to HDL ratio.
Go to the following site, sponsored by the US National Library of Medicine. [url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=PubMed"]http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=PubMed[/url]
Type in policosanol then press GO.
You will find a significant amount of peer reviewed studies on the effect of policosanol on cholesterol.
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