4th January 2008
Folks I wanted to post these studies and reference articles (FYI: Dilantin=Phenytoin):
First a study by Elson So (now at the Mayo Clinic) and J. Kiffin Penry (deceaesed): Adverse Effects of phenytoin (Dilantin) on poeripheral nerves and neuromuscular junction: A Review; Epilepsia (1981) 22(4) 467-73.
Phenytoin and Thyroid hormone action; J Endriconology (1985), 104(2), 201-4
Serum GGT (gamma-glutamyl transpeptidase) activity in patients on long term phenytoin therapy Digestive Diseases and Sciences (1988) 31(10) 1056-61: Conclusion GGT levels are higher in folks on LT dilantin therapy.
Phenytoin and cerebellar lesions: Similar Effects on Catecholamine metabolism: Archives of neurology (1977) 34(3) 162-7
Effect of long term phenytoin treatment on the levels of Calcium and Magnesium in rat femurs: Comptes Rendus des seances de la Societe de biologie et de ses filiales (1978) 172(6) 1114-8: phenytoin reduces bone calcium and magnesium levels w/o effecting plasma levels of calcium or magnesium
Peripheral neuropathy in children on long term phenytoin therapy: Brain and Development (1981) 3(4) 375-83
I have to head to work now but here are some of the references that might be of interest. I still have to find the apirin reference which I have and when I do I will post :)
First a study by Elson So (now at the Mayo Clinic) and J. Kiffin Penry (deceaesed): Adverse Effects of phenytoin (Dilantin) on poeripheral nerves and neuromuscular junction: A Review; Epilepsia (1981) 22(4) 467-73.
Phenytoin and Thyroid hormone action; J Endriconology (1985), 104(2), 201-4
Serum GGT (gamma-glutamyl transpeptidase) activity in patients on long term phenytoin therapy Digestive Diseases and Sciences (1988) 31(10) 1056-61: Conclusion GGT levels are higher in folks on LT dilantin therapy.
Phenytoin and cerebellar lesions: Similar Effects on Catecholamine metabolism: Archives of neurology (1977) 34(3) 162-7
Effect of long term phenytoin treatment on the levels of Calcium and Magnesium in rat femurs: Comptes Rendus des seances de la Societe de biologie et de ses filiales (1978) 172(6) 1114-8: phenytoin reduces bone calcium and magnesium levels w/o effecting plasma levels of calcium or magnesium
Peripheral neuropathy in children on long term phenytoin therapy: Brain and Development (1981) 3(4) 375-83
I have to head to work now but here are some of the references that might be of interest. I still have to find the apirin reference which I have and when I do I will post :)