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   Any health effects with long term use of Nexium? (Acid Reflux board)

12th May 2005
Quote from TJN:
Blondie :) I don't know what to say other than ask him again , what he told you as far as PPIS eliminating all acid in the stomach is not at all accurate. . There is no single pill on earth that can completely shut the acid down . I can 1000 percent guarantee that. Email Astra Zeneca and ask them.


As for acid serving no purpose ....Everything in the body serves a purpose. Acid is very important in killing bacteria as well. People can live with no acid though , just like they can live without a gallbladder , although some may have digestive problems , develop atrophic gastritis, malabsorption syndrome B 12 diffiency, bacterial related infections etc .

As for the ph test, it does not measure how much acid is in the stomach. There is a different test for that. The ph measures acid exposure to the esophagus ONLY. Not the stomach.

Do you understand how a ph test works? It counts reflux episodes. Any drop in the ph below 4 for 4 seconds or longer is defined as one reflux episode. If you have less than 50 of these reflux episodes, and your ph is above 4 for 95 percent of the total time in a 24 hour period, you are getting sufficient acid suppression.
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Yes, my doctor did tell me that I have to be very careful about bacteria and food poisoning and such. Maybe he was exagerrating.

As far as the pH probe is concerned- I had two probes. One was placed in my esophogus, one in my stomach. On the computer two numbers were displayed- one was my stomach's pH, the other was my esophogus pH. The purpose of the test was to determine how well the PPIs were working, which is why they wanted. The answer was not very well, since both numbers rarely went above 4. My first probe was done on 80mgs of Nexium, my second on 60mg of Prevacid.

I;ve also tried Reglan with Prevacid, and didn't tolerate it. I have Carafate and Phenergan as needed, but those aren't really controllers. I have been doing a lot of reading, like I said, and pretty much decided fundoplication is next, but neither one of the 2 GIs I see is a huge fan of that. Since you have been doing a lot of reading too, what do you think I should be looking more into. I'm also realizing I have LPR symptoms- sore throat, horseness, random voice loss. I have asthma as a result of reflux (and my asthma doctor is pushing for a fundo), and have torn a hole in my esophogus and thrown my electrolytes out several times from vomiting. I'm just not sure where to go from here. I'm thinking adding Zantac 300 or Erythromyacin.
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