I have been on Protonix for 4 yrs and stil has the acid reflux, only someday is better than the other. A couple of months ago I tried to reduce taking it, only took it when I need it, because I read that there is no study yet on long term side effects if taking PPI more than 3 yrs.

Since I still get this acid reflux, now my doctor wanted to switch with Nexium, I got free samples but couldn't take them, so I am back taking Protonix again.
Right now I take it everyday since my voice is hoarse for one month already.
Don't know if this is from side effects of PPI or the acid reflux itself. I read that both can make our voice hoarse. Can't win.

Now there is a new study that taking Zantax, Pepcid AC for a long time could cause Dementia, but no study yet on PPI.