I used them both. They are almost the same. It is up to you to pick a phasic vs. mono-phasic pill. I lost weight on both of them. I had no initial break-outs with any. When I started getting headaches on Ortho-Cyclen after a year of using, I switched to Tri-cyclen. Didn't make a difference in side effects. Headache was gone for a while. Then came back. But I tolerated it well. In short, if you want to delay your period by taking the pill without taking a break -i.e continous cycling- which I don't recommend, then take Cyclen because with multi-phasic pills it is not a good idea to do it.

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Peace!