Hello,

I experienced significant increase appetite and weight gain almost immediately after my first set of epidural injections. My face got puffier too where people actually noticed and once my aunt, a nurse (who did not have knowledge of my injections at the time) asked if I was on steroids. So, yes, I do believe that steroid injections do cause weight gain. However, the pain in my back and neck did decrease and I was also taking Mobic which also causes water retention. I asked my doctor how long the epidural lasts in your system and she said about 4 weeks. After that time, my appetite and weight went back to normal. It is also not recommended to get the injections more than every 12 months.