I'm on my second pack of Desogen. I noticed that I broke out right when starting the second pack, maybe from the lack of hormones the week before? When I was on Yasmin for 3 months I broke out during the placebo week. I'm thinking of switching to Mircette since it has some extra estrogen the last week, but the overall estrogen dose is low so I'm not sure if overall it would be good for my acne.