I am on Zoloft 25mg, Xanax .25 as needed, and 25 mg. of Metoprolol 2x a day. I have had no problems with it, at least nothing noticeable. I am on it for a high heart rate/random eposide of atrial fibrillation. My anxiety has gotten better over the last several months so I don't think it has caused hightened anxiety....just makes me a little sleepy if anything (and I'm not even sure if it does that). I take it around 9am and 9pm. Hope it works for you! Let me know if you have any other questions! :)