I know the feeling and sympathize with you. I just finished a round of Macrobid for a bladder infection and I was sick as ever (I have gastritis and acid reflux--so it was not fun at all). I had to take 2 a day (or every 12 hours). I took one in the morning and one before bed. The morning one was the worse! I was told to take the medication with food to avoid the nausea which I did and it didn't really help the first couple of days. I did find that when my stomach was empty is when the nausea was the worse so I kept crackers with me all the time and nibbled on them which helped a little. The nausea did eventually go away after the first few days and hopefully the same goes for you! :)