Hi Sadie & Lisa.....My brother 2 years ago had black out spells and was hospitalized for almost 2 months. Everytime he stood up he would pass out. He had a tilt table test which showed the worst positive results the cardiologist and neurologist had ever seen. They diagnosed him with a form of POTS that they had never seen. He was released on lopressor and changed to topranol and functions pretty well until Saturday. At that time he presented with uncontrollable tremors involving all 4 extremities and his head and neck violently twitching for over 3 hours. He cannot walk....my SIL has to carry him on her back otherwise he'll black out. He has taken his max of 400mg of topranol which barely controls his headache and twitching. A cardiologist is presently working him up for pheochromocytoma on a 24 hour urine test.....my sister in law just called and said that his tremors are worstening since he can't take the topranol while on the urine test and she is calling an ambulance. I see that there are some here that have an understanding of this disease and any help would be appreciated. thanks......Goody