Since I first injured my back a year ago, my anti-inflammatory of choice has been Lodine. I also take the generic brand (etodolac). My doctor told me that it is better to take it once a day instead of breaking up the dosage and that it works best when it is in your system for a few days. Whenever I have a flare up of pain as I did just last week, I rely on Lodine to get me through. I have not experienced any side effects, but I believe that it can effect your liver if taken for long periods of time. My doctor recently did blood work to make sure that my liver functioning was fine. Prior to having surgery, it was the only thing that relieved any of my symptoms. I hope this helps.