I have been on Estrostep for 3 months now. The first two months I had a tiny bit of nausea (just a couple of days) and my periods were lighter, but I had really bad cramps the first 2 days of my period both months (worse than when I wasn't taking bc pills). The 3rd month I had some spotting which worried me so I called my doctor and I was also experiencing a lot more nausea. I told her about the spotting and she didn't seem too worried about it, but since I was having terrible cramps she decided to switch me to Levlite, which I will begin taking on Sunday. Overall, it wasn't bad for me excpet the cramping, but its different for everyone. Good Luck!*