Hi i was put on this isosorbide mononitrate 10 mg twice a day today and i have headaches too and have just come out of hospital had this done angio-seal because i was getting bad chest pains what are you taking for the headaches so i can sort mine out please :)
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had angioplasty on the 7-09-06

had a pci + stent x1 to cx/ stent.drug eluting
all so have unstable angina


lanzoprazole 30mg
plavix clopidogrel 75mg
asprin 75mg
bisoprolol 10mg
simvastatin 80mg
isosorbide mononitrate 40mg twice a day
gtn spray

I take isosorbide and was told by doc and verified by pharmacist that the medication is coronary arteries specific for dilation. ACE inhibitor and coreg (beta blocker) are systematic vessel dilators. I inquired because it is for angina, and I didn't have angina! But to dilalte the corornary arteries may be beneficial even if there is no pain?!

I don't have any headaches, but your regimen greatly differs from mine. My regimen is a beta blocker (coreg), ACE inhibitor (lisinopril), lassix (diuratic), for contractions (digitek) and isosorbide to dilate coronary arteries.

I just read an interesting case study of an elderly man who developed a predilection for CLUSTER headaches after being introduced to isosorbide-mononitrate. WHen the drug was removed, the illness went away, when it was reintrduced, back came the headaches. In fact DURING the clusterr episode, which can go on for days, with EACH dose, the headache would return with a vengeance.

The discussion cleared up a mystery for me. I have occasional bouts with migraine/cluster and was always struck by the ease with which a known vasodilator caused splitting headaches but yet beta-blockers, KNOWN vasodilators are used to cure such headaches. There seemed to be a paradox.
The case study confirmed that the massive headache started just AFTER the effect of the nitrite peaked. My answer: the reactive vasoCONSTRICTION causes the pain.
Until I find better evidence, that will remain my hypothesis. If my theory is correct, then the SLOWER the nitrate/nitrite acts, the less likely the headache.

KK,
[QUOTE]I take isosorbide and was told by doc and verified by pharmacist that the medication is coronary arteries specific for dilation
I think this is a case, like the parallel with beta blockers, that the term "specific" can range from "sorta specific" to "very slightly specific."
Any reference to ISMN is ALWAYS accompanied by the caveat: "often causes hadache."

Thanks everyone headache's gone and i feel gr8 now what a different isosorbide mononitrate 10 mg twice a day has made i feel like a new man:)

QUOTE:Thanks everyone headache's gone and i feel gr8 now what a different isosorbide mononitrate 10 mg twice a day has made i feel like a new man

That is my daily dose also, and no problems.