I've taken Zoloft ever since it hit the market about l2 or l3 years ago. I have never been happier or more well-adjusted. It worked wonders for me and to this day I still take the same low dosage I started on--25 mg. a day. I doubt if I will ever go off it since I think I was born depressed and now have a new lease on life. I have no side effects whatsoever. I officially take it with Inderal to halt my lifetime of migraines, and it does that too. I've been virtually pain-free most of these years with only one or two migraines a year instead of daily pain.