I don't know how many others can relate, but I've been taking antidepressants for about 2 years, trying a few different medications. They seem to work for a while and then offer absolutely no relief. Recently, I've been getting bad headaches, have trouble sleeping, am always exhausted, along with a constant stream of many very negative thoughts. I am beginning to think that there is no medication that can provide solid relief. I just know I can't live my life like this. I was on Celexa for over a year, and have been on Effexor recently (which my psychiatrist said was the most effective medication available.)