The only side effects I have had with it was nausea and that subsided after 3 days of using it. I have been using it in combination with differin so I don't know if its the differin or the mino that brought a few spots out. Then again, the spots that did come were only three and they are already starting to go away a lot faster then when I first started- I just saw a derm and she wanted me to stay on the same thing for awhile longer. I guess my question was since I am stopping mino is that bringing out new pimples? Also- I have red spots from leftover from spots I got so I am hoping those go away with time. I don't mind the red spots as much as I hate getting new pimples!~