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   Coumadin and Soy Milk (Blood and Blood Vessel board)

27th August 2007
Has anyone had experience with the effect of soy milk on PT/INR when taking coumadin?
My husband has been on coumadin since 1996. There have been a few times when it had been out of range, but has always gone back pretty quick.
He was told that his cholesterol is 297 at the end of May this year. He changed his diet to include whole grains by eating cereal with soy milk (he is lactaid intolerant.) Looking back his PT/INR has been out of range since then. At first it was way too low at 1.7. He is having his levels checked every 2 weeks - sometimes once a week when it is way out of range. His coumadin dose has gone from 6MG to 9 1/2 MG since the beginning of May. Finally 4 weeks ago it was back in range. Last Thursday he was tested again (after two weeks) his PT/INR was 5.7. They reduced his coumadin to 9 MG with another test scheduled for this Thurs.
He was started on Crestor for his cholesterol 3 weeks ago. Since then he has dropped off from eating cereal 4 -5 times a week to once or twice a week.
I've been reading on the Internet and found several references to soy products and PT/INR problems. I called his cardiologist's nurse today and asked her about it. She called back and said the Dr. said to call a pharmacist because the Dr. didn't know if soy interacted with coumadin.
We called one pharmacist and he didn't know but said he would check and call back.
Has anyone on coumadin had problems with soy products? I'm thinking that he should stop drinking soy milk and see what happens - but is this dangerous with his PT/INR at 5.7 and still on 9MG of coumadin? Please let me know if any of you have any information on this.
Thanks for your help.
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