My son had the same reaction to Vyvanse (30mg). Would not eat; would not sleep (of course he has this with most anything he's on - my doc says it's fine to give him one of the OTC natural sleep pills when he needs it); upset stomach; and headaches. We tried Focaline XR (20mg) and he ate good but it didn't last long enough in the day. They don't make a 30mg pill and I can't swing two Rx a month so we're back on Concerta but next higher dose.