What other approach may you suggest? I have been on Duricef and Erythromycin before with no sucess, have used Retin-A gel and micro, Differin, Plexion, Duac, and am currently using Brevoxyl 4%, T-stat, and Cleocin T solution on top of the Minocyclin. I have tried many things with no sucess, including OTC cleansers and such as well as several holistic treatments (B-5, etc.) The topicals and cleansers work good but not good enough to reduce the cystic, painful, unsightly, scar causing acne on my back. Which is what led me to ask if taking 200mg 1x before bed would be ok such as to avoid the dizzy vertigo feeling. I have inquired about Accutane to my derm, but my liver enzymes were elevated so he denied me the treatment.