I have recently started Cymbalta.....20mg twice daily. Currently, I take one in the morning and one at dinner time. I also take 2mg of Cardura at dinner time (for high BP and Raynaud's disease). Around 8pm, I experience such a crashing fatigue. It is indescribable. I can't focus and could fall asleep the minute I sit down. My question....has anyone else experienced such a fatigue from Cymbalta? I don't know if it is the Cymbalta causing the drowsiness; or the Cardura.

Also....has anyone experienced nauseousness while taking Cymbalta? If so, does this eventually subside?

Lastly, how long does it take before I can begin to feel the effects of Cymbalta....days? Weeks?

Thanks so much for any help you can give me!