I was on Protonix for 2 months, after Prevacid and Nexium stopped working. Then Protonix stopped working.. I think partly because of the Biaxin I'm on for Lyme Disease. So I switched to Aciphex.. but my stomach hurt much worse, so I decided to take Zantag and see if it does anything. I hate taking meds, but the pain is overwhelming at times. :(