I was put on ortho when I had really bad acne about 2 and a half years ago, and never had a bad experience, and I have stayed on it ever since even just for the other benefits. But that wasnt the sole thing I had. I had some face creams that were used in combination that changed throughtout (Differin, Benzamycin, and Retin-a Micro) and my skin cleared up extremely quick. I havent had acne (other than the general pimple or 2) since like.. 2003. But like other people said, I'm no doctor, and that's just my experience, everyone's bodies are different.