I would'nt mix any PPI's unless you asked the doctors,always asked them before taking more than you should too. I know you can take antacids with a PPI and you can take antispasmatics with them too. I was on an antispasmatic until the GERD was under control. They are Bentyl, donnatol and hysocomine and im sure more. They calm your digestive tract and they calmed me to. My anxiety was almost gone, They are not for everyone but it did help me. Your doc can tell you more.