14th July 2006
Hey all. I just wanted to post this info I found. I cut and pasted important parts. The info was found in ****pedia.
Oxycodone is an agonist opioid, and as such is a variation on an ancient theme beginning with the simple consumption or smoking of the alkaloid-bearing parts of Papaver somniferum, the opium poppy, first cultivated circa 3400 BC in lower Mesopotamia. Ancient Sumerians, Assyrians, Babylonians, and Egyptians found that smoking the extract derived from the seedpods yielded a pleasurable, peaceful feeling throughout the body.
Oxycodone is a semi-synthetic opioid derived from the alkaloid thebaine, unlike most early opium-derived drugs which instead used the morphine or codeine alkaloids also found in the plant. Oxycodone was first synthesized in a German laboratory in 1916, a few years after the German pharmaceutical company Bayer had stopped the mass production of heroin due to addiction and abuse by both patients and physicians. It was hoped that a thebaine-derived drug would retain the analgesic effects of morphine and heroin with less of the euphoric effect which led to addiction and over-use.
To some extent this was achieved, as Oxycodone does not "hit" the central nervous system with the same immediate punch as heroin and does not last as long. The subjective experience of a "high" was still reported for Oxycodone, however, and it made its way into medical usage in small increments in most Western countries until the introduction of the Oxycontin preparation radically boosted Oxycodone use.
The introduction of OxyContin in 1995 resulted in increasing patterns of abuse. Unlike Percocet, whose potential for abuse is limited by the presence of acetaminophen, OxyContin contains only OXYCODONE and inert filler. Abusers either wash off the coating and crush the tablets to defeat the time-release mechanism, then either ingest the resulting powder orally, intranasally, via intravenous/intramuscular/subcutaneous injection, or rectally to achieve rapid absorption into the bloodstream. Injection of OxyContin is particularly dangerous since it contains binders which enable the time release of the drug. Often mistaken as the time release, the outside coating of the pill is merely used as a color code for different dosage amounts.
It was once felt that "combination" opioids (those that contain one or more additional, non-narcotic ingredients) would be less subject to abuse, since, for example, the amount of acetaminophen present in large overdoses of Percocet would cause stomach upset and liver damage. However, it has been demonstrated that abusers seeking the euphoric "high" are not deterred by these potential side effects or toxicities.
Oxycodone has similar effects to morphine and heroin, and appeals to the same abuse community.
SO.. they created it as a substitute for Heroin, which would be less deadly and addictive. LOL
And I did not know Oxycontin is oxycodone with some inert filler thrown in. Interesting stuff.
Oxycodone is an agonist opioid, and as such is a variation on an ancient theme beginning with the simple consumption or smoking of the alkaloid-bearing parts of Papaver somniferum, the opium poppy, first cultivated circa 3400 BC in lower Mesopotamia. Ancient Sumerians, Assyrians, Babylonians, and Egyptians found that smoking the extract derived from the seedpods yielded a pleasurable, peaceful feeling throughout the body.
Oxycodone is a semi-synthetic opioid derived from the alkaloid thebaine, unlike most early opium-derived drugs which instead used the morphine or codeine alkaloids also found in the plant. Oxycodone was first synthesized in a German laboratory in 1916, a few years after the German pharmaceutical company Bayer had stopped the mass production of heroin due to addiction and abuse by both patients and physicians. It was hoped that a thebaine-derived drug would retain the analgesic effects of morphine and heroin with less of the euphoric effect which led to addiction and over-use.
To some extent this was achieved, as Oxycodone does not "hit" the central nervous system with the same immediate punch as heroin and does not last as long. The subjective experience of a "high" was still reported for Oxycodone, however, and it made its way into medical usage in small increments in most Western countries until the introduction of the Oxycontin preparation radically boosted Oxycodone use.
The introduction of OxyContin in 1995 resulted in increasing patterns of abuse. Unlike Percocet, whose potential for abuse is limited by the presence of acetaminophen, OxyContin contains only OXYCODONE and inert filler. Abusers either wash off the coating and crush the tablets to defeat the time-release mechanism, then either ingest the resulting powder orally, intranasally, via intravenous/intramuscular/subcutaneous injection, or rectally to achieve rapid absorption into the bloodstream. Injection of OxyContin is particularly dangerous since it contains binders which enable the time release of the drug. Often mistaken as the time release, the outside coating of the pill is merely used as a color code for different dosage amounts.
It was once felt that "combination" opioids (those that contain one or more additional, non-narcotic ingredients) would be less subject to abuse, since, for example, the amount of acetaminophen present in large overdoses of Percocet would cause stomach upset and liver damage. However, it has been demonstrated that abusers seeking the euphoric "high" are not deterred by these potential side effects or toxicities.
Oxycodone has similar effects to morphine and heroin, and appeals to the same abuse community.
SO.. they created it as a substitute for Heroin, which would be less deadly and addictive. LOL
And I did not know Oxycontin is oxycodone with some inert filler thrown in. Interesting stuff.