I used it for two weeks and it didn't do anything for me at all. My derm said that I didnt give it enough time, but when I have been on other similar meds in the past I usually see a difference in a week or less. Not with this though. He gave me a bunch of samples for it, then when I ran out he wrote me a prescription for it, but I didnt fill that at my pharmacy yet.. Last week I was put on bactim for cystic acne which was pretty severe, today, ONE WEEK later I am COMPLETELY clear... Bactrim is a godsend for me