I never took Singular because I researched the drug . Last year my asthma which I had for 20 years got much worse and I was coughing and coughing. Azmacort wasn't helping anymore and I needed Ventolin, 8 puffs a day; so I went to a new doctor who wanted to put me on Singular but I told him I had read about flu-like symptoms,etc which he pooh-poohed but I asked him to try me on something else. I tried Flovent inhaler and it has worked; I still use Ventolin , 2 puffs a day. He wanted me to try Advair but I don't like combination drugs because if you have a reaction it is difficult to determine which drug is causing the problem. Anyway, I am glad I never used Singular; I think people need to do a little research before just taking something and if they have a concern to discuss it with their physician.