I have taken all the drugs for MS except Rebif. I am currently taking Tysabri. I have only had two infusions with the third next week. I am at the infusion center for about 2 1/2 hours. The first infusion I had a very mild headache for about a week, the 2nd infusion I got the same mild headache but it only lasted one day. I think I feel better (more energy) but as Nikki said it probably takes a few more infusions really know.
I was on Copaxone for about 8 years. I didn't get any new lesions until the last MRI. This is why I changed and went on Tysabri.
I have taken ACTH (pre CRAB days) Azathioprine (pre CRAB days), Betaseron, Avonex, Copaxone, Novantrone (two maximum treatment sessions) and now Tysabri. I have been lucky and had minimal side effects. I really didn't notice anything using any of them but I have had MS symptoms at least 25 years and I attribute the use of these drugs for slowing the progression of the disease.
Candy