I've tried effexor and inderal. Didn't help me at all. The medication that has worked best for me is Axert. 12.5 mg, no side effects just relief. Inderal was very hard for me to get off of when I stopped taking it. I had alot of withdrawal from it. I recently started taking Topomax also. I think it helps but not as much as I would like it to. Because I believe alot of my migraines are due to peri-menopause I have started taking an all natural product called Brevail. I don't seem to have as many headaches and the positive aspect of it all is it also decreases your appetite! You can find information about it at www.brevail.com. Good luck and hopefully we can all find relief without all the medication!