I wont pretend that I know how heart problems play into other medications or if any would help but there are a lot. Metformin, Avandia, Glyburide, Starlix, Actos off the top of my head. There are some in the same class as the one you already take, ones that increase insulin production, and then there are many others in different classes. Ones that help your cells use insulin, ones that make the insulin your body produces better (real scientific huh?!), ones that slow down the digestion of starch and sugar, all kinds. Even within the general functions there are different ones.

For instance starlix and glimepiride essentially do the same thing, stimulate your body to produce insulin. However glimepiride works for 24 hours so you usually only take it once, maybe twice a day, but starlix works only for a few hours so you take it before each meal, your body is whipped into producing a bunch of insulin and you keep your glucose levels under control after meals and then it leaves your body.

Like I said, I'm no doctor so I don't know if you can take any of those, I do know that there are warnings about heart problems with some of them but I don't know why they are there or how they would fit in with you personally but it seems strange that your doctor would say that you would only try 2 different meds and then go on insulin.

Another question I have is what type of doctor do you go to see? If you only see a family doctor then I would highly recommend seeing an endocrinologist who specializes in diabetes.