I've been on metformin for two years with the actos and with avandamet, which is Avandia plus metformin. I went to the ER last night and the doc there thinks it's my gall bladder, did some x rays, some blood work, gave me a shot of demerol and phenergren and sent me home with a script for vicodin. Guess what? Vicodin doesn't touch the pain once the demerol wore off. I hurt like all get out...I'll have to go back to the ER tonite again. I'm scheduled for a sonagram on Wed and a scopy thing on thurs. I've had all the gall bladder tests, scoped up and down from both ways, nuclear med scans, MRI, ultrasounds, etc....everything was fine in December. But then I was having horrible nausea and GERD, now i'm having PAIN...