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   Avalide and Side Effects on my brain (High & Low Blood Pressure board)

13th February 2007
appalbarry,
Since AVALIDE is a combo of two drugs (AVAPRO + HCTZ), ask your doctor for samples of a SEPARATE ARB (Cozaar, Diovan, or Avapro, whichever he has lying around) and also some HCTZ.
Try each in turn to see which one has you in a brain fog. (You can also see which is most responsible for controlling your BP.)
26th April 2007
I have been on avalide for a year and have been so confused have trouble walking very unsteady and shaky. always feel like i am in a fog.
26th April 2007
Appalbarry's post is an old one but it was a godsend because I reported these same symptoms to my doctor this morning and he more or less denied my reality--seems he has no other patients with similar side effects. Barry's old post reminded me that I am not crazy...

I am responding to "Barry" with the hope that someone else is an a similar situation right now and will benefit by the information we offer.


[QUOTE]Been taking Avalide since being diagnosed ten years ago. Of late I'd swear it's messing up my brain.

I can't concentrate, make all sorts of small errors with numbers and dates, can't focus on tasks, forget things.

Yes, I understand this quite well--I had a similar experience over a period of about 2 years--actually got "fired" from a "temp job" because I didn't have the concentration to address 25 envelopes properly----and I graduated with honors from college and I "Aced" graduate school! Other concentration problems I became aware of had to do with driving through FAMILIAR stop signs, and near misses on the road despite never having been in an accident and no previous moving traffic violations.

[QUOTE] Occasional dizziness, sometimes nearing blackouts. Vision issues. Really it's impacting me pretty significantly.

Yes, I experienced these symptoms as well. I changed my eyeglass prescriptions three times over 3 years (blamed the poor old eye doc on this) only to return to my "old" eyeglasses after changing bp meds. You're not crazy!! I've since learned that diuretics can change the pressure in the eye and this is a side effect that my gp, optometrist, nor my ophthalmogist were aware of...

[QUOTE]Finally, after my latest doctor had nothing to offer, I went so far as to take half pills for few days.

Bang! I was clear as bell and got more quality work done in a week than in the last month. Obviously this is not an ideal solution.

Now as I look back I'd swear that I can see a steady deterioration over at least a couple years. Nothing you could really pin down, just a lessening in my capacity to function. It's only recently when it seemed to be genuinely debilitating that I began to put the pieces together.

Yes, this is understandable and explainable. But reducing the dosage may be the solution (if it keeps your bp down). I began to put the puzzle together in bits and pieces after I'd forgotten a dose of medication--it wasn't until months afterward when the "brain fog" had lifted that I began to see the whole picture and began finding documentation that supported my experiences (brain fog, vision problems, etc).

As we get older, the fat, water, and muscle composition of our bodies changes. Also our liver function normally decreases (sometimes as much as 50 percent!). These are factors that impact the way we metabolize or break down our medications. As a result, the older we get the more likely it is that we need LESS of a med!! Not all doctors are aware of this but geriatric practitioners are (you don't have to be "old" for this to happen, it's just these doctors know more about it!). Oh, and for the record, the "real" drug problem in our country is in the older adult population and this is one of many reasons for that.

[QUOTE]I have dropped from 200 lbs to 170 in the last few years, and am working out regularly.

Again, fat and muscle content can impact the amount of medication that is needed depending on how the drug is metabolized in the body.

[QUOTE]I'm feeling that it's not entirely my imagination.

It's definitely not, definitely not your imagination! I know...my doctor doesn't believe me either, but I know, I know, I know. I experienced this for over 2 years while taking hydrochlorothiazide!

Barry, Lenin offers some helpful advice but I'll put in my 2 cents worth. I know I had concentration and vision problems while taking hydrochlorothiazide. I had many other problems as well (shoulder and back pain, EXHAUSTION, etc) but you only mention the concentration and vision so I would suspect the hctz.

Although I feel badly that you are going through this, your post offers me such comfort because it reinforces my belief that I am not crazy.

Bless you for sharing.

Bsheba
28th April 2007
having same problem with avalide walk around in a daze my walking is unsteady i am very shaky can't sleep like i did. taking 300mg. cut it in half feel a little better. let me know how you are doing this med has very bad side effects i don't know about you but i have a lot of twitching in leg and arm and numbness
29th April 2007
Just for your information, appalbarry hasn't responded for months so he probably won't be getting back to you.

It is interesting that you are experiencing twitching in your arms and legs and I, too, experienced twitching in my arms and legs (and was diagnosed with periodic limb movement syndrome) and was confused and experienced what I've seen referred to as "brain fog"...this was my experience on hydrochlorothiazide, which according to Lenin, makes up a part of your avalide. My symptoms disappeared when I discontinued the medication.

Yes, for me the hydrochlorothiazide had extremely bad side effects---but I didn't know how bad they were until I was off the medication!! I do hope you consult with your doctor and try something else. I say this because the "brain fog" impaired my good judgement making driving (among other things) dangerous for me and for the others who were on the road with me.

Bsheba
18th August 2007
add one more to your list avalide stinks ever since i am taking it i donT walk right loose my balance twitching in shoulder an hand jerks dtop things i feel like i forgot ho to walk right.i have been taking this for year ever since then havent been feeling right
janet
21st August 2007
I AM NEW HERE HAVE THE SAME PROBLEM SINCE Taking avalide. my jerks very confuseddont walk right feel like i forgot how to walk goig to neurologist tomorrow kind of scared hope it is nothing serious would appreciate any help
thanks love this board have been looking at it for a long time
janet(sisterp
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