RYR is a weak statin (lovastatin) that is available over the counter..it works in the liver exactly the way that a very small dose of Liptor (atorvastatin) does.

Welchol is a bile sequestrant that prevents the cholesterol rich bile from being reabsorbed by the liver and thus passes a lot of cholesterol out with the feces. These bile sequestrants are only available Rx in the U.S. ANy problems with this drug will likely be harmless diarrhea and maybe some cramping.

Yes, they will work well together.

Trouble with the RYR though, there are NO legal requirements for standardized dosage, safety, efficacy, etc...you may be getting an empty placebo. It's strictly "let the buyer beware."