14th September 2004
"10+10=80"
In a study of 628 patients with primary hypercholesterolemia, ezetimibe plus 10 mg of atorvastatin was more effective than atorvastatin 10 mg, 20 mg, or 40 mg in lowering LDL-C levels. In fact, the LDL-C–lowering efficacy of 10 mg of ezetimibe plus 10 mg of atorvastatin was similar to 80 mg of atorvastatin. One method used to remember this clinical finding is the "formula" of "10 + 10 = 80."
Ballantyne CM, Houri J, Notarbartolo A, et al., for the Ezetimibe Study Group. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial. Circulation 2003;107;2409-2415.
In a study of 628 patients with primary hypercholesterolemia, ezetimibe plus 10 mg of atorvastatin was more effective than atorvastatin 10 mg, 20 mg, or 40 mg in lowering LDL-C levels. In fact, the LDL-C–lowering efficacy of 10 mg of ezetimibe plus 10 mg of atorvastatin was similar to 80 mg of atorvastatin. One method used to remember this clinical finding is the "formula" of "10 + 10 = 80."
Ballantyne CM, Houri J, Notarbartolo A, et al., for the Ezetimibe Study Group. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial. Circulation 2003;107;2409-2415.