rahod, "I would try 10mg+Zetia first.... 20Mg Crestor +Zetia will almost certainly get you there."

Rahod, I hope your right, but so far, although I respond to statins, I have not responded to them as well as baseline reduction statistics would predict.

In fact, if I had responded to Pravachol as well as the CRESTOR people say I should, I'd already be at good levels. I'm not.

Here is what Elena Citkowitz, the Director of Cholesterol Management Center at Yale University School of Medicine says about people with FH:

"Because 50% of the LDL receptors are normal, these patients have an excellent response to the usual cholesterol-lowering drugs. However, LDLc elevations are so severe that treatment still remains difficult.

Maximum doses of one of the stronger HMG-CoA reductase inhibitors (ie, statins) such as atorvastatin or rosuvastatin and one or more other medications, including bile acid sequestrants or niacin, are required to approach the recommended LDLc goals"

Get that last bit..."to approach the recommended LDLc goals"

You're telling me I'll run faster if I use CRESTOR running shoes...maybe, but the real problem is, I only have one leg...LOL.

mark

Quote from mhtyler:

rahod, "I would try 10mg+Zetia first.... 20Mg Crestor +Zetia will almost certainly get you there."

Rahod, I hope your right, but so far, although I respond to statins, I have not responded to them as well as baseline reduction statistics would predict.

In fact, if I had responded to Pravachol as well as the CRESTOR people say I should, I'd already be at good levels. I'm not.

Here is what Elena Citkowitz, the Director of Cholesterol Management Center at Yale University School of Medicine says about people with FH:

"Because 50% of the LDL receptors are normal, these patients have an excellent response to the usual cholesterol-lowering drugs. However, LDLc elevations are so severe that treatment still remains difficult.

Maximum doses of one of the stronger HMG-CoA reductase inhibitors (ie, statins) such as atorvastatin or rosuvastatin and one or more other medications, including bile acid sequestrants or niacin, are required to approach the recommended LDLc goals"

Get that last bit..."to approach the recommended LDLc goals"

You're telling me I'll run faster if I use CRESTOR running shoes...maybe, but the real problem is, I only have one leg...LOL.

mark

From a study:
Each doubling of the statin dose produces an incremental LDL-C reduction of approximately 5–6% of the baseline LDL-C value, resulting in a further LDL-C reduction of 15–18% with a three step doubling of the statin, compared with the LDL-C reduction achieved with the statin starting dose. The addition of 6 tablets of colesevelam or the addition of 10 mg of ezetimibe to 10 mg of a statin results in about the same level of LDL-C lowering as 80 mg of the statin. The highest doses of statins are most associated with adverse side effects.

Do a search for 'Lipids on line" web site..then do a search for "Ezetimibe" on that home page and go to slide 21..sorry I wish I could post the link. That graph says it all.