Well, I feel for you guys - I'm also using that amount (1.25) of xopenex in my nebulizer - don't have the patience to do it 4 times a day, so usually just 1-2 times...but I still don't feel like I'm completely under control. I use salenterol (sp?), asmanex, nasonex, singular, astelin - besides the xopenex nebulizer and inhaler...It can take some "tweaking" to get the meds right, but I don't feel terrible enough right now to go for a "tune up" with my lung doc...I'm triggered by weather changes/fog/cold, and respiratory infections...hang in there!