Well, Boniva is a newer bisphosphonate than pamidronate (Aredia) which may have to do w/the short infusion time. I'm not too interested in doing such a short infusion time for any bisphosphonate simply becuase I did experience that very mild tingling at the lips and wrists at the 2 hour drip rate. I don't know that the tingling really meant anything at all but since I did experience it and Mayo quickly responded to my mention of it I would just naturally be leery of having any medication of the same class infused in such a short time as they are recommending for Boniva. That's just me. I'm just a patient, not a doctor. But since I'm the one who gets to experience the good, the bad and the ugly of any medication we try .... I'm just not a real brave soul when it comes to medications!