I have been on Methotrexate for a couple of years now. No problems except occasional nausea and tiredness, not bad though. My doctor also said no more than 1-2 drinks per week. I probably have 1-2 once a month. I really miss my cocktails though. I am also on Arava. I think the combination of the two have really helped me, although I still have alot of inflammation. I am getting ready to start on Humira injections. Hopefully that will help.